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Thursday, July 17, 2008 4:46 PM
posted by Aric Thorpe, MHR

Neonatal risks posed by mothers taking psychotropic drugs during pregnancy

Currently, there is very little known about neonatal risks posed by mothers taking psychotropic drugs during pregnancy. However, two studies have provided some new data on neonatal outcomes associated with psychotropic drugs. The following is an excerpt of an article from Journal Watch that discusses the findings:
Using large medical, demographic, and public drug insurance registries in Quebec, researchers focused on women with psychiatric diagnoses (mostly, mood or anxiety disorders) and antidepressant use for at least 1 month in the year before pregnancy. Researchers compared first-trimester antidepressant exposure and duration in 2140 healthy infants and 189 infants with any major congenital malformation in the year after birth. Antidepressants commonly used were paroxetine (42%), sertraline (15%), and venlafaxine (13%). The risk for congenital malformation (8%, vs. the usual population rate of 3%) was unrelated to first-trimester antidepressant use, its duration, or therapeutic class. Controlling for ethnicity and for drug, alcohol, and tobacco use, determined in 806 mothers, did not alter results.

Other researchers linked maternal and neonatal British Columbian health records to identify recipients of a serotonin reuptake inhibitor… <click here to read the rest of this article from Journal Watch>

Severe psychiatric conditions should be treated at the discretion of a psychiatrist and at the consent of an educated patient or guardian during pregnancy. However, due to the relatively little known effects of psychotropic drugs on neonatal outcomes cognitive-behavioral therapy should be considered by physicians as an alternative to addressing anxiety and depression during pregnancy.

Click here for more information on the treatment of depression

Click here for more information on the treatment of anxiety disorders

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Stephen Harnish, MD is the Medical Director of Brookhaven Hospital. He is board certified in psychiatry, and is a graduate of Dartmouth Medical School. Dr. Harnish is a member of the American Psychiatric Association and is well known in Oklahoma for his informative radio and television appearances.


Rev Robert Wester, MDIV MA is Senior Chaplain at Brookhaven Hospital and the RENEWAL programs. Chaplain Wester conducts daily devotional services and offers pastoral counseling to clients in the RENEWAL program.


Aric Thorpe, MHR, is Brookhaven Hospital's Pastoral Liaison Representative. He conducts the quarterly Minister's Lifeline series and provides mental health information to pastors and clergy.


Sarah McGee, BA, serves as the Community Education Provider for Brookhaven Hospital. She provides information on mental health and drug and alcohol treatment to healthcare professionals in Oklahoma and surrounding states.

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